Antinociceptive and Anti-inflammatory Effects of Hydroalcoholic Extract of Female Cones of Juniper (Juniperus excelsa) and Plantago ovata in Male Wistar Rats

Methods: In this study, 144 male Wistar rats were used. To investigate the analgesic and anti-inflammatory effects of each extract using formalin and xylene test, the animals were divided into 6 groups. The groups received hydroalcoholic extract of female cones of Juniper (at doses of 50, 100, 150, and 200mg/kg) and hydroalcoholic extract of Plantago ovata (at doses 10, 50,100, and 150mg/kg) orally by gavage for 28 days. The control groups (normal saline recipients) and positive control (receiving morphine at dose of 10mg/kg in the pain group or dexamethasone at dose of 15mg/kg in the inflammatory group), were considered for each extract. One-way ANOVA and Tukey's post hoc test were used to determine the difference between the groups.