The Cytotoxic Effects of Hydroalcoholic Extract of Aerial Parts of Scrophularia striata on MCF-7 Cell Line and Evaluation of BAX and KAI1 Genes Expression | Zendy

Mohadesehsadat Tabatabaee | Zendy; Rahim Ahmadi | Zendy; ُSeyed Mehrdad Kassaee | Zendy

Open Access

The Cytotoxic Effects of Hydroalcoholic Extract of Aerial Parts of Scrophularia striata on MCF-7 Cell Line and Evaluation of BAX and KAI1 Genes Expression

Author(s) -

Mohadesehsadat Tabatabaee,

Rahim Ahmadi,

ُSeyed Mehrdad Kassaee

Publication year - 2018

Publication title -

qom univ med sci j

Language(s) - English

Resource type - Journals

eISSN - 2008-1375

pISSN - 1735-7799

DOI - 10.29252/qums.12.9.38

Subject(s) - cytotoxic t cell , mcf 7 , traditional medicine , gene , cell culture , biology , line (geometry) , genetics , medicine , cancer , in vitro , cancer cell , human breast , geometry , mathematics

Methods: In this laboratory experimental study, at first, extract of the plant was prepared using maceration method. The effect of different concentrations of the extract (0.001, 0.001, 0.1, 1, and 10mg/ml) was investigated on the viability of MCF-7 cells using MTT assay method. Also, the effects of doses of 1, 0.1, and 0.01mg/ml of the extract, was evaluated on BAX and KAI1 genes using real-time PCR. The data were analyzed using one way AN0VA test.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research