The Effect of Decreased Activity in the Form of Neuropathic Pain on GSK-3β Gene Expression in Sciatic Nerve Fiber of Male Wistar Rats | Zendy

Masoud Rahmati | Zendy; Mokhtar Ghanbarzadeh | Zendy; Mohammad Hassan Aghaei | Zendy

Open Access

The Effect of Decreased Activity in the Form of Neuropathic Pain on GSK-3β Gene Expression in Sciatic Nerve Fiber of Male Wistar Rats

Author(s) -

Masoud Rahmati,

Mokhtar Ghanbarzadeh,

Mohammad Hassan Aghaei

Publication year - 2018

Publication title -

qom univ med sci j

Language(s) - English

Resource type - Journals

eISSN - 2008-1375

pISSN - 1735-7799

DOI - 10.29252/qums.12.2.11

Subject(s) - sciatic nerve , neuropathic pain , nerve fiber , medicine , endocrinology , nociception , gene expression , anesthesia , gene , anatomy , biology , receptor , genetics

Accepted: 10 Jan, 2017 Abstract Background and Objectives: Studies have shown that impairment in kinases in the nervous system is related to many neurodegenerative disease. Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase that participates in regulation of various functions of neurons. Accordingly, GSK-3β is one of the drug targets for nervous system therapies. In this study, the effect of decreased activity in the form of neuropathic pain, was investigated on GSK-3β gene expression in sciatic nerve fiber of male Wistar rats.

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