A Comparative Survey of the Effects of Fluoxetine and Imipramine on Depression-Like Behavior and Serum Levels of Corticosterone and Glucose in Male Rats under Immobilization Stress | Zendy

Razieh Bayramlou | Zendy; Mehdi Mohammadzadeh | Zendy; Farin Babaei Balderlou | Zendy

Open Access

A Comparative Survey of the Effects of Fluoxetine and Imipramine on Depression-Like Behavior and Serum Levels of Corticosterone and Glucose in Male Rats under Immobilization Stress

Author(s) -

Razieh Bayramlou,

Mehdi Mohammadzadeh,

Farin Babaei Balderlou

Publication year - 2018

Publication title -

qom univ med sci j

Language(s) - English

Resource type - Journals

eISSN - 2008-1375

pISSN - 1735-7799

DOI - 10.29252/qums.12.2.1

Subject(s) - fluoxetine , corticosterone , imipramine , endocrinology , medicine , depression (economics) , serum glucose , psychology , serotonin , hormone , diabetes mellitus , receptor , alternative medicine , pathology , economics , macroeconomics

Methods: In this experimental study, 24 male Wistar rats (age range, 180±20gr), were used. Animals were divided into four groups of 6 each, including: Control, under immobilization stress, fluoxetinetreated (dose, 20mg/kg), and the Imipramine-treated (dose, 30mg/kg). Induction of immobilization stress was conducted by limiting polyethylene for 14 days. At the end of the treatment period, the antidepressant effects of the drugs in the treatment groups, were evaluated using tail suspension test. Then, serum levels of corticosterone and glucose, were measured.

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