Investigation of the Possible Association between Human Cytomegalovirus and Pterygium Development | Zendy

Mishar Kelishadi | Zendy; Mandana Kelishadi | Zendy; G. Hossein Ashrafi | Zendy; Alijan Tabarraei | Zendy

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Investigation of the Possible Association between Human Cytomegalovirus and Pterygium Development

Author(s) -

Mishar Kelishadi,

Mandana Kelishadi,

G. Hossein Ashrafi,

Alijan Tabarraei

Publication year - 2019

Publication title -

medical laboratory journal

Language(s) - English

Resource type - Journals

ISSN - 2538-4449

DOI - 10.29252/mlj.13.4.1

Subject(s) - pterygium , cytomegalovirus , medicine , human cytomegalovirus , virology , immunology , ophthalmology , virus , herpesviridae , viral disease

Background and Objectives: Pterygium is a common ocular surface lesion that manifest as wing-shaped, benign conjunctival growth, which can extend onto the corneal surface. Presence of some oncogenic viruses in pterygium and the neoplastic nature of the lesion led us to the postulated involvement of the viruses in the etiology of pterygia. The aim of this study was to evaluate prevalence and possible role of human cytomegalovirus (HCMV) in the formation of pterygia. Methods: Fifty pterygium specimens and 10 normal conjunctival biopsy specimens (controls) were investigated by polymerase chain reaction using primers specific for the highly conserved regions of major capsid protein gene of HCMV. Data were analyzed using SPSS statistical software (IBM SPSS Statistics 18; IBM Corporation, USA) at significance level

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