Comparison of cytokine levels IL2, IL6, TNFα in brain death and living donors and its relationship with early renal graft function in the recipients in Shiraz Namazi Hospital in 2008-9

which can lead to renal graft dysfunction in the , Brain death leads to increased activity of cytokine iewing the cytokine levels in brain death donors and living ones and This study aims at rev . recipient . their relationship to early renal graft function in recipients : Methods from brain , patients who had received kidney transplant 104 control study was conducted on This case α TNF , ) 6 Interleukine ( 6 IL , ) 2 Interleukine ( 2 IL Serum levels of cytokines . death and living doners in the donors before transplantation and serum creatinine levels and urine ) α Tumor necrotizing factor ( . output after operation in the recipients were measured : Results and the rest ) 1 group ( eath donors received kidney from brain d ) 60.6% ( cases 63 , Of all the patients The urine output and creatinine changes in the two groups were ). 2 group ( from the living donors α and TNF , 6 IL , 2 There were high levels of IL . no significant differences were found ; similar over time before transplantation and a statistically significant difference was observed in brain death donors levels before transplantation was higher in those who 6 IL . between brain death and living donors ificant difference donated kidney to the group suffering from acute rejection and there was a sign . between the groups not undergoing rejection : Conclusion . there are high levels of cytokines in brain death donors before transplantation , Based on the results is associated with an increase in acute rejection in kidney 6 the serum level of IL , Among them . ansplantation tr