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The application of herbal plants instead of synthetic drugs has been increasing in recent years because of their lower side-effects and high varieties of efficient components. An investigation on antinociceptive and anti-inflammatory effects of hydroalcoholic extract of Nepeta menthoides seems to be necessary due to the existence of its components. Materials and Methods: This study was done on 224 NMRI male mice weighing 20-25 g. Xylene-induced ear edema and Formalin test were used for demonstrating its anti-inflammatory and anti-nociceptive effects. Results: The hydroalcholic extract had no toxic effect. This study showed that Nepeta menthoides aerial parts have anti-inflammatory effect at all doses, particularly at dose of 2800 mg/kg and significantly decreased nociception in chronic phases. The dose of 2800 mg/kg had the most anti-nociceptive effect in chronic phases. Meanwhile, in the immersion test, nociception decreased at a dose of 1400 mg/kg significantly. Conclusion: Hydroalcoholic extract of Nepeta menthoides has anti-nociceptive and anti-inflammatory effects. These effects might be due to its Nepetalactone and 1,8 cineole components.

Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice