Sr-doped bioactive glasses for biological applications | Zendy

Zahra Moazzami Goudarzi | Zendy; Amir Ijadi | Zendy; Ameneh Bakhriari | Zendy; Sara Eskandarinezhad | Zendy; Negar Azizabadi | Zendy; Mohammadreza Asgari Jazi | Zendy

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Sr-doped bioactive glasses for biological applications

Author(s) -

Zahra Moazzami Goudarzi,

Amir Ijadi,

Ameneh Bakhriari,

Sara Eskandarinezhad,

Negar Azizabadi,

Mohammadreza Asgari Jazi

Publication year - 2020

Publication title -

journal of composites and compounds

Language(s) - English

Resource type - Journals

eISSN - 2716-9650

pISSN - 2676-5837

DOI - 10.29252/jcc.2.2.7

Subject(s) - fourier transform infrared spectroscopy , scanning electron microscope , nuclear chemistry , bromide , simulated body fluid , osteoblast , infrared spectroscopy , mineralogy , materials science , chemistry , analytical chemistry (journal) , chemical engineering , chromatography , in vitro , biochemistry , organic chemistry , engineering , composite material

In the present study, sol–gel derived BGs based on 60% SiO2-(36-x) CaO-4P2O5-x SrO (where x = 2, 4, 6 and 8 mol%) system were synthesized. The effect of Sr on bioactivity and proliferation of G292 cells was investigated. X-ray diffraction analysis (XRD), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were utilized to study the obtained phases, HA morphology, and its functional groups, respectively. The XRD and FTIR tests showed that the rate of hydroxyapatite formation on sample 2S was higher than that of other samples. The 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay after one day immersion in SBF, showed that the viability of the samples containing 6 mol% Sr (6S) increases by increasing immersion time, while the sample containing 8 mol% Sr (8S) showed a decrease in bioactivity in osteoblast G292 cells proliferation. According to the results 6S BG specimen with 6 mol% SrO exhibited appropriate bioactivity and cell proliferation.

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