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Background: Gastric cancer is the fourth most common cancer and the second most common cause of cancer-related death around the world. Northern areas of Iran from northwest to northeast have a high risk of this cancer. Genetic mutations and changes in expression level are the most effective factors in carcinogenesis and cancer progression. CFL1 is one of the genes affected by changes in expression level. CFL1 is isoform of the ADF/cofilin protein family. The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. In this research, we studied the expression of this gene in intestinal samples of gastric adenocarcinoma. Material and Methods: In this study, mRNA was extracted from the intestinal type of gastric adenocarcinoma of 26 biopsy samples. Next, real-time polymerase chain reaction was performed to measure gene expression after cDNA synthesis. Results: The rate of CFL1 gene expression in tumor samples significantly increased compared with healthy tumor margins (p<0.05). Furthermore, the biomarker index for CFL1 was obtained 0.88. Conclusion: This gene can be used as a biomarker in gastric cancer. Overall, the results of this study showed that the expression of CFL1 has a significant association with the nature of cancer tumors. This implies that CFL1 has a high potential as a novel target for gene therapies in gastric cancer.

CFL1 Gene Expression in the Intestinal Samples of Gastric Adenocarcinoma in East Azarbaijan Population