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Bladder cancer is one of the most common causes of malignancy. The eighth cause of death is due to cancer and is responsible for three percent of the total tumors. The purpose of this study was to evaluate the effect of drinking water nitrate on bladder cancer in Larestan. Method: This is a descriptive-analytic study in which two types of data are used. Blood cancer data from Larestan Health Center and nitrate data collected from Larestan rural water and sewage company. The standardized incidence rate of 1000 people was prepared for each separate section and the disease zoning map was based on this indicator in three groups of low risk, medium and high risk in GIS. The nitrate concentration map was prepared by interpolation method in GIS. Finally, using Pearson correlation in SPSS, the relationship between uric acid and nitric oxide was studied. Results: Bladder cancer is the third most common cancer in Larestan province with 58.3% in men and 41.7 in women. The main focal points of the disease in the city are the Saharany Bagh and Byram departments, respectively. The main concentration of nitrate in the parts of the Evaz, the Saharay Bagh and Byram. Comparison of these focuses with the concentration map of nitrate of drinking water (areas with nitrate between 20-45 mg / l) showed that these areas coincide (with correlation coefficient r = 764 and p = 0.038). Conclusion: Considering the association between nitrate and bladder cancer in this study. Therefore, a more detailed study of the subject in terms of water elements and other factors affecting bladder cancer is necessary.

Investigation of the relationship between drinking water nitrate and bladder cancer in Larestan city from the point of view medical geography