The Effect of Swimming Training on Serum Levels of Sex Hormones, Antioxidant Enzymes and Oxidative Damage of DNA Ovarian Tissue in Rats with Polycyclic Ovarian Syndrome | Zendy

Mehdi Noura | Zendy; Samane Rafie | Zendy; Seyed Ali Hosseini | Zendy; Mohammad Amin Edalatmanesh | Zendy

Open Access

The Effect of Swimming Training on Serum Levels of Sex Hormones, Antioxidant Enzymes and Oxidative Damage of DNA Ovarian Tissue in Rats with Polycyclic Ovarian Syndrome

Author(s) -

Mehdi Noura,

Samane Rafie,

Seyed Ali Hosseini,

Mohammad Amin Edalatmanesh

Publication year - 2020

Publication title -

annals of applied sport science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.159

H-Index - 4

eISSN - 2476-4981

pISSN - 2322-4479

DOI - 10.29252/aassjournal.861

Subject(s) - antioxidant , hormone , endocrinology , ovarian tissue , medicine , oxidative stress , oxidative phosphorylation , enzyme , oxidative damage , biology , ovary , biochemistry

Background. Hormone disorders, stress-oxidative and inflammation in ovarian tissue cause noovulation in women with polycyclic ovarian syndrome (PCOS). Several studies have shown the role of exercises in control of sex hormones. Objectives. The aim of this study was to investigate the effect of 6 weeks of swimming training (ST) on serum levels of sex hormones, antioxidant enzymes and oxidative damage of DNA ovarian tissue in rats with PCOS. Methods. In this experimental study, 30 female Wistar rats were divided into 3 groups included control, PCO (letrozole consumption for 28 days intraperitoneally) and PCO+ST groups. PCOS was induced with 28 days of peritoneal injection of 1 mg/kg letrozole. The ST program was included 6 weeks of ST for 20 minutes per day. At the end of the treatment period, serum levels of LH, FSH, testosterone, estradiol and progesterone, SOD, CAT, GPX, MDA and HOdG-8 in ovarian tissue were measured by ELISA method. Results. ST significantly decreased serum levels of LH, estradiol, testosterone, MDA and HOdG-8 levels (p<0.05) as well as increased SOD, CAT, and GPX enzymes of rats with PCOS (p<0.05). Conclusion. It appears that ST has antioxidant and sex hormone enhancing effects in ovarian tissue of rats with PCOS model.

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