Synthesis of Biphasic Calcium Phosphate and its Behaviour in Simulated Body Fluid

Hydroxyapatite [Ca10(PO4)6(OH)2, HA] is commonly used as bioactive materials in bone graft, orthopaedic application, dental implant etc. since its unique ability to bond to bone after implantation (Ellinge et al. 1986). The ability of bond to bone can be predicted by its capacity to form HA layer on the surface upon immersed in simulated body fluid (SBF) solution, of which the ion concentrations is similar to human plasma (Nery et al. 1990). SBF screening is commonly used to predict the ability to bond to bone since its simplicity and economic, before implant into a live animal. In the other hand, the β-tricalcium phosphate [β-Ca3(PO4)2, β-TCP] is known as biodegradable materials, but exposes its weak bioactivity (Petrov et al. 2001). So if we can combine HA and β-TCP with proper ration, we are also possible to control the advantage of biphasic calcium phosphate (BCP): high bioactivity and its fast biodegradation (Victoria & Gnanam 2002; Aslanidou et al. 2012).