Open AccessTHE SYNTHESIS OF A NOVEL BIBENZOPYRAN RELIED ON ELECTROOXYDATION OF MALLOAPELTA B BY CYCLIC VOLTAMMETRY
Author(s) -
Phan Thi Binh,
Bui Hai Ninh,
Châu Văn Minh,
Nguyễn Hoài Nam,
Lê Mai Hương,
Phan Văn Kiệm
Publication year - 2017
Publication title -
asean journal on science and technology for development
Language(s) - English
Resource type - Journals
eISSN - 2224-9028
pISSN - 0217-5460
DOI - 10.29037/ajstd.210
Subject(s) - cyclic voltammetry , hep g2 , ic50 , chemistry , cytotoxicity , nuclear chemistry , chromatography , in vitro , electrochemistry , electrode , biochemistry
A novel bibenzopyran named bimalloapelta (1) was synthesized relying on electrooxydation of malloapelta B by cyclic voltammetry in acetonitril adding LiClO4 0.1 M as supporting electrolyte. Its structure determination based on extensive NMR studies and ESI mass spectral measurements. The new compound showed significant cytotoxicity againsts two cancer cell lines as human hepatocellular carcinoma (Hep-2; IC50 : 0.46 μg/m) and rhabdosarcoma (RD; IC50: 0.33 μg/m). These results were the same that of malloapelta B (Hep-2, IC50: 0.49 μg/ml and KB , IC50: 0.54 μg/ml).
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