Open AccessMaximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline
Author(s) -
Koutsoumanis Konstantinos,
Allende Ana,
AlvarezOrdóñez Avelino,
Bolton Declan,
BoverCid Sara,
Chemaly Marianne,
Davies Robert,
De Cesare Alessandra,
Herman Lieve,
Hilbert Friederike,
Lindqvist Roland,
Nauta Maarten,
Ru Giuseppe,
Simmons Marion,
Skandamis Panagiotis,
Suffredini Elisabetta,
Andersson Dan I,
Bampidis Vasileios,
BengtssonPalme Johan,
Bouchard Damien,
Ferran Aude,
Kouba Maryline,
López Puente Secundino,
LópezAlonso Marta,
Nielsen Søren Saxmose,
Pechová Alena,
Petkova Mariana,
Girault Sebastien,
Broglia Alessandro,
Guerra Beatriz,
Innocenti Matteo Lorenzo,
Liébana Ernesto,
LópezGálvez Gloria,
Manini Paola,
Stella Pietro,
Peixe Luisa
Publication year - 2021
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2021.6864
Subject(s) - oxytetracycline , chlortetracycline , doxycycline , tetracycline , antimicrobial , antibiotic resistance , antibiotics , microbiology and biotechnology , biology , food science , veterinary medicine , toxicology , medicine
The specific concentrations of tetracycline, chlortetracycline, oxytetracycline and doxycycline in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for these four tetracyclines was estimated. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tetracycline, chlortetracycline, oxytetracycline, whilst for doxycycline no suitable data for the assessment were available. Uncertainties and data gaps associated with the levels reported were addressed. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for these antimicrobials.