Using Technology to Enhance Clozapine Prescribing Guidelines

Background Clozapine is the most effective antipsychotic for the management of treatment-resistant schizophrenia [1], however, it continues to be under prescribed [1]. Adverse-effects of Clozapine, are one of the contributing factors leading to its low prescription rate [1], due the significant morbidity and mortality related to Clozapine. In order to monitor and prevent these complications, evidence based practice guidelines recommend dietary modifications, stool softeners and scheduled absolute neutrophil counts (ANC) [2]. In this study, we explore the effectiveness of how a Clozapine provider order sets (CPOS) in an Electronic Medical Records (EMR) system, improves compliance to evidence based practice guidelines; to ensure prevention of Clozapine adverse drug events, and thus, possibility increasing Clozapine use.