Mean platelet volume and platelet distribution width levels in discoid lupus erythematosus patients: A case-control study

Aim: Platelets (PLT) play an important role in inflammatory reactions and immune responses. This study aims to evaluate PLT and PLT parameters in patients with discoid lupus erythematosus (DLE), which is characterized by inflammation. Methods: In this case-control study, a total of 125 participants, consisting of 60 DLE patients and 65 healthy controls, were selected to participate. PLT, platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), the ratio of neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes (PLR) were studied retrospectively in both groups. Results: The mean age of the patient group was 47.30 (15.14) years, and the mean age of the control group was 38.08 (13.33) years. There were no statistically significant differences between the PLT, PDW, MPV, PCT, NLR and PLR levels in DLE patients and healthy controls (P=0.365, P=0.988, P=0.160, P=0.851, P=0.898 and P=0.887, respectively). Conclusion: To the best of our knowledge, there are no reports on both PLT, PDW, PCT, NLR, PLR and MPV in patients with DLE. We did not find a significant difference in the DLE group. PLT parameters are low-cost tests that can be used to define inflammation levels in inflammatory diseases. Further prospective studies on this subject will contribute to this work.