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Toksik epidermal nekroliz (TEN), ilaclar, enfeksiyonlar ve maligniteler tarafindan tetiklenen nadir, akut ve ciddi bir advers reaksiyondur. Ilaclar hastaligin ana nedenidir. En yaygin ilaclar sulfonamidler ve penisilinlerdir ve en sik iliskili bulasici ajan herpes simplex virusudur. Allopurinol, gutta serum dusurucu tedavi icin ilk sira ilactir ve ABD Gida ve Ilac Idaresi (FDA) tarafindan onaylanmaktadir. Son arastirmalarda, allopurinolun yasami tehdit edici ilac reaksiyonlarina neden olan en yaygin iliskili ilac oldugu bulundu. Burada, allopurinolun neden oldugu nadir bir TEN vakasi, TEN'in tedavisinde intravenoz immunoglobulinlerin kullanimi (IVIg) ve yuksek doz sistemik kortikosteroidlerin etkinligini/zararlarini sunmayi amacladik.

Treatment of allopurinol-induced toxic epidermal necrolysis with high dose corticosteroids and intravenous immunoglobulins