Treatment of allopurinol-induced toxic epidermal necrolysis with high dose corticosteroids and intravenous immunoglobulins | Zendy

Zeynep Gizem Kaya İslamoğlu | Zendy; Mehmet Akyürek | Zendy

Open Access

Treatment of allopurinol-induced toxic epidermal necrolysis with high dose corticosteroids and intravenous immunoglobulins

Author(s) -

Zeynep Gizem Kaya İslamoğlu,

Mehmet Akyürek

Publication year - 2019

Publication title -

journal of surgery and medicine

Language(s) - Turkish

Resource type - Journals

ISSN - 2602-2079

DOI - 10.28982/josam.540023

Subject(s) - medicine , allopurinol , toxic epidermal necrolysis , dermatology , gastroenterology

Toksik epidermal nekroliz (TEN), ilaclar, enfeksiyonlar ve maligniteler tarafindan tetiklenen nadir, akut ve ciddi bir advers reaksiyondur. Ilaclar hastaligin ana nedenidir. En yaygin ilaclar sulfonamidler ve penisilinlerdir ve en sik iliskili bulasici ajan herpes simplex virusudur. Allopurinol, gutta serum dusurucu tedavi icin ilk sira ilactir ve ABD Gida ve Ilac Idaresi (FDA) tarafindan onaylanmaktadir. Son arastirmalarda, allopurinolun yasami tehdit edici ilac reaksiyonlarina neden olan en yaygin iliskili ilac oldugu bulundu. Burada, allopurinolun neden oldugu nadir bir TEN vakasi, TEN'in tedavisinde intravenoz immunoglobulinlerin kullanimi (IVIg) ve yuksek doz sistemik kortikosteroidlerin etkinligini/zararlarini sunmayi amacladik.

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