Clinical manifestations of cytomegalovirus and other infections in infants

Cytomegalovirus (CMV) is a common infectious pathology, diagnosed in newborns. This infection plays a significant role because of the possibility of severe generalized process, congenital malformations, and potential risk of developing chronic disease [1, 2]. The clinical manifestation of the disease with the possible development of an extremely severe forms observed in patients with acquired immunodeficiency or physiological nature, which is characteristic, for example, for infants [3]. The clinical manifestations of infection with intrauterine infection mechanism (IUI) are different. Therefore, it is interesting to study the clinical manifestations of CMV infection and to compare them with other infections in young children. Objective: to study the clinical manifestations of CMV infection in infants, and compare with systemic lesions in other infections with fetal development mechanism. Materials and methods. A total of 57 infants were examined with clinical manifestations of disease, which could be the cause of intrauterine infection. To confirm the diagnosis of body fluids from sick children (blood, saliva) investigated the presence of cytomegalovirus genome, herpes simplex virus 1 and 2 of types, Chlamydia, Mycoplasma, Ureaplasma, Toxoplasma (by PCR) and specific IgM antibodies and low avidity antibodies Class IgG (ELISA). The study protocol includes methods such as neurosonography, skull radiography, computed tomography of the brain. All 57 patients were divided into 4 groups: 26 children with cytomegalovirus infection (group 1), 10 an infection caused by the herpes simplex virus (SPGV) 1-2 second type (group 2), 8 with toxoplasmosis (Group 3), 13 with chlamydia (Group 4). Statistical analysis of the results was performed using the application package Statistica 6,0 to aggregate data to Microsoft Excel 2000 on the PC. Determined by the average value of indicators (M), standard errors were calculated average values of these parameters (m), we evaluated the accuracy of the average value of the differences in the two groups using the Student t-test. Results and discussion. In the study of the clinical manifestations of CMV infection found that nerve damage was observed in 100% of cases, including the damage of the nuclei of cranial nerves in 2 children (1.6%), convulsive seizures or convulsive readiness in 10 (10.6%), hypotonia in 27 (56.7%), hyporeflexia 26 (50.5%), strabismus in 18 (15.7%), nystagmus in 4 (5.6%), tremor 8 (32.5%). Meningitis diagnosed in 6 children (3.3%), meningoencephalitis 4 (2.2%), ventriculitis 14 (7.8%). In 40 patients (78.6%) was found hydrocephalic syndrome, in 2 (3.3%) microcephalic, signs of intracranial hypertension were found in 16 children (53.9%). One child (0.5%) diagnosed with uveitis, 3 patients (1.6%) retinopathy, in 1 (0.5%) hearing loss. Revealed neurosonographic signs: choroid plexus cysts (52.2%), ventriculomegaly (78.6%), symptoms of acute intraventricular hemorrhage (7.3%), the presence of periventricular calcifications located in the brain (25.8%), angiopathy CLINICAL MANIFESTATIONS OF CYTOMEGALOVIRUS AND OTHER INFECTIONS IN INFANTS