AGO unchained Canonical and non-canonical roles of Argonaute proteins in mammals | Zendy

L. Sala | Zendy; Srividya Chandrasekhar | Zendy; Joana A. Vidigal | Zendy

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AGO unchained Canonical and non-canonical roles of Argonaute proteins in mammals

Author(s) -

L. Sala,

Srividya Chandrasekhar,

Joana A. Vidigal

Publication year - 2019

Publication title -

frontiers in bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.117

H-Index - 143

eISSN - 1093-9946

pISSN - 1093-4715

DOI - 10.2741/4793

Subject(s) - argonaute , psychological repression , biology , microrna , non canonical , computational biology , microbiology and biotechnology , gene , genetics , rna , rna interference , gene expression

Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex that promotes both decay and translational repression; the siRNA pathway represses transcripts through direct Ago2-mediated cleavage. Here, we review our current knowledge of mechanistic details and physiological requirements of both these pathways and briefly discuss their implications to human disease.

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