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Objectives.1. To demonstrate that vaginal tightening results improve at the progestational phase of the cycle. 2. To assess if menstrual cycle can be a conditioning factor in the results of vaginal tightening. Method: Descriptive, comparative, cross-sectional study conducted on 20 women who attended consultations between October 2017 and December 2017. Two sessions with fractionated CO 2  laser and intravaginal handpiece were performed. The day of the cycle was taken into account to carry out the vaginal tightening, and Likert’s scale was applied to the month of each session. Results: The sample group included 20 women, most of them between 29 and 39 years of age (60% = 12 cases). A statistically significant association between the phase of the menstrual cycle and the level of friction during sexual intercourse after the second session was found. Women who reported a high degree of friction during sexual intercourse at the second tightening session registered a higher average of days of menstruation than those who reported a moderate degree of friction. This difference was statistically significant. Conclusion: It was possible to determine in the study that the progestational phase improves the results of vaginal tightening with up to 100% and that menstrual cycle can be considered a conditioning factor for the results. Key words:  vaginal cycle, vagina, vulva, CO2 laser, vaginal hiperlaxity, rejuvenation, tightening

HISTOLOGICAL CHANGES IN THE EPITHELIUM OF THE VAGINA: ARE THEY IMPORTANT IN THE RESULT OF THE INTRAVAGINAL LASER TREATMENT?