Efeito preemptivo do ibuprofeno na dor pós-operatória associada à exodontia de terceiro molar : ensaio clínico randomizado duplo-cego cruzado comparando doses múltiplas versus dose única

Postoperative pain management still represents a challenge for some clinicians, and its severity and duration can be reduced by preemptive analgesia, defined as an antinociceptive treatment that prevents the establishment of altered central processing of afferent input, responsible by amplification of postoperative pain. Nineteen participants underwent extraction of bilateral lower impacted third molars were enrolled in a randomized clinical, double-blind, crossover clinical trial, which was compared using single dose (SD, 600mg of ibuprofen, oral, 1 hour before surgery) versus multiple doses (MD, 600 mg ibuprofen 25, 19, 13, 7 and 1 hour before surgery). The primary outcome was reduction of postoperative pain, measured by using a visual analogue scale (VAS) immediately and 3, 8 and 24 hours after surgery. Secondary outcomes were reduction of degree of mouth opening, consumption of rescue analgesics (codeine 30 mg, orally) and measurement of the pain threshold by Semmes-Weinstein filaments application (Δlog force g), 24 hours after the surgery. The MD group showed less pain (VAS) compared with the control at 3 and 8 hours after surgery (22±21 vs. 37±29, 27±22 vs. 37±34; MD vs. SD, 3h and 8h respectively, P = 0.03). There was no difference with respect to the secondary outcomes. In conclusion, the use of multiple doses is superior to single dose of ibuprofen as preemptive analgesia strategy associated with surgical removal of impacted lower third molar.