Synthesis, characterization of new nicotinamide-oxazole analogs, and their antimicrobial activity

Identi ication of a novel antimicrobial molecule is vital to research due to contaminated agro related products and harmful pathogens. Especially, candida albicans is the most common infective fungi in the world that causes hospitalacquired infections. There is amedical and biological need for the discovery of novel antimicrobial drugs with high potent in nature. This effort involves the synthesis of scaffold molecule in which vitamin B3 and oxazole play vital role as pharmacophoremoiety, where 2-(Nicotinamido) oxazole-4-carboxylic acid couples with pyridine–3-carboxylic acid (nicotinic acid) and 2-aminooxazole derivatives. Then, it is carried for mass spectra, H NMR spectroscopy, and growth control ability study against microbial targets such as fungi and bacteria. The zone of inhibition is measured in millimeters for the serially diluted solution of the compound. From the outcomes, the compound (5i) displayed 35mmof inhibition zone area, but standard luconazole showed29mmfor250 ppm solution. The outcome revealed that the amide bond and oxazole moiety turn as imperative pharmacophore besides showing decent inhibition activities.