Lightening up Ruthenium Complexes to Fight Cancer? | Zendy

Cristina Mari | Zendy; Gilles Gasser | Zendy

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Lightening up Ruthenium Complexes to Fight Cancer?

Author(s) -

Cristina Mari,

Gilles Gasser

Publication year - 2015

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2015.176

Subject(s) - photodynamic therapy , pact , ruthenium , cancer , cancer treatment , skin cancer , chemotherapy , cancer cell , cancer research , medicine , chemistry , pharmacology , combinatorial chemistry , biochemistry , political science , catalysis , law , organic chemistry

In medicine, light is used in a medical treatment called photodynamic therapy (PDT) to treat some types of cancer and skin diseases. This technique generally allows for reduced side effects compared to traditional chemotherapy. However, PDT is not fully effective on hypoxic tumors (i.e. lacking oxygen). To overcome this important drawback, photoactivated chemotherapy (PACT) agents have been designed to obtain light-mediated cancer cell death via an oxygen-independent mechanism. Ruthenium complexes have already been and are currently deeply explored as traditional anticancer agents. However, as reported in this short review article, such compounds can also bring novel opportunities in the field of light-mediated cancer treatment. Herein, we report on our findings in the optimization of Ru(II) polypyridyl complexes as PDT and PACT agents for the potential treatment of cancer and, interestingly, also of bacterial infections.

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