New Trends in Fast Liquid Chromatography | Zendy

Dao T.T. Nguyen | Zendy; Davy Guillarme | Zendy; Serge Rudaz | Zendy; JeanLuc Veuthey | Zendy

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New Trends in Fast Liquid Chromatography

Author(s) -

Dao T.T. Nguyen,

Davy Guillarme,

Serge Rudaz,

JeanLuc Veuthey

Publication year - 2007

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2007.186

Subject(s) - chromatography , high performance liquid chromatography , throughput , sample (material) , sample preparation , chemistry , analytical chemistry (journal) , materials science , process engineering , computer science , engineering , telecommunications , wireless

Analytical laboratories are currently interested in enhancing overall productivity by increasing sample throughput and reducing analysis time. Different approaches are proposed in liquid chromatography (LC) to perform fast or ultra-fast separations with cycle times of less than 5 or 1 min, respectively. Among these approaches, the use of monolithic supports, high temperature LC (HTLC), short columns and ultra-performance LC (UPLC) are described and compared in this study. A comparison of the above LC approaches is presented through Knox curves and pressure plots based on experimental data. Fast separations of pharmaceutical compounds are presented in order to illustrate the interest of these techniques and compare them with conventional LC separations

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