Open AccessMatrixmetalloproteinase-9 gene polymorphism (rs 17576) increases the risk of depressive symptoms in bipolar disorder
Author(s) -
Kothandan Saravanan,
Neha Keshri,
Hanumanthappa Nandeesha,
Vikas Me,
Alladi Charanraj Goud
Publication year - 2022
Publication title -
journal of neurosciences in rural practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 22
eISSN - 0976-3147
pISSN - 0976-3155
DOI - 10.25259/jnrp-2022-6-34
Subject(s) - young mania rating scale , medicine , genotype , allele , bipolar disorder , minor allele frequency , allele frequency , gastroenterology , polymorphism (computer science) , genetics , mania , gene , biology , lithium (medication)
Plasticity of neural synapses is known to be involved in the complications in bipolar disorder (BD) patients. Matrix metalloproteinases (MMPs) play a role in synaptic plasticity and memory. Even though elevated MMP-9 levels are reported in neuropsychiatric disorders, there is limited data about MMP-9 gene polymorphism in BD. The objectives of the study was to investigate genotype frequency and allele frequency of MMP-9 genetic variant (rs 17576) in BD and its association with disease severity.