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The aim of this study was to determine the physical and chemical stabilities of tablets containing Sonchus arvensis L leaves extract and Lumbricus rubellus. The tablets were produced by wet granulation process. The stability test was observed during a 3-month accelerated stability under 40 ± 2oC and 75 ± 5% RH storage conditions. The tablets were evaluated every month for the physical properties include organoleptic, weight variation, friability, hardness, and disintegration time, while the chemical properties of the tablets include Rf value, and spotting profile was examined using TLC-Densitometry. The result of the physical stability test up to the third month showed that the tablets of Sonchus arvensis leaves extract and Lumbricus rubellus met the requirements of Indonesian Pharmacopeia 5 and United State Pharmacopeia 32. The qualitative chemical property stability test on the tablets also demonstrated that luteolin as a marker compound remained stable in the tablets after three months of storage in an accelerated condition. Conclusion, the formulation of a tablet containing Sonchus arvensis leaves extract and Lumbricus rubellus stable after this stability studies.

Physicochemical Stability Studies of Tablet Containing A Mixture of Sonchus Arvensis L Leaves Extract and Lumbricus rubellus Powder