Evaluation of Incisional Diabetic Wound Healing Activity of Ethanolic Leave Extract of Mimosa pudica L. in Rats

Diabetes mellitus (DM) is a fast growing epidemic throughout the world. India is going to become the capital of DM. DM patients are at greater risk of serious infective foot ulcer or wound. The diabetic wound may be associated with late healing and septic manifestation and finally reach to limb amputation which is an overpriced incident. The herbal products are more precious in both prophylaxis as well as curative in delayed diabetic wound healing activity when compare to synthetic drugs. The present study was carried out to evaluate the diabetic incisional wound healing activity of ethanolic leave extract of Mimosa pudica L. (EMP) in Streptozotocin (55 mg/kg, i.p.) induced diabetic rats. A wound of 1cm incision was made on ventral side of diabetic male albino wistar rats. The two different doses (2.5% and 5%) of EMP are applied on wound b.i.d for 11 days. The initial and final fasting serum glucose levels were estimated to confirm the disease state. The breaking strength and histopathological studies of incisional healed skin was estimated. The EMP 2.5 % and EMP 5% have shown significant (p>0.01) increase in wound breaking strength as well as well epithelialization compared to diabetic control group.