Open AccessStudy the Effect of Vitamins (C and E) on Oxidative Stress and Antioxidants Changes Induced by VCM in Male Rats
Author(s) -
Shaymaa J. Shamran,
Haider Salih Jaffat
Publication year - 2020
Publication title -
international journal of pharmaceutical quality assurance
Language(s) - English
Resource type - Journals
ISSN - 0975-9506
DOI - 10.25258/ijpqa.11.3.20
Subject(s) - vitamin e , oxidative stress , vancomycin , antioxidant , vitamin c , vitamin , malondialdehyde , anti oxidant , endocrinology , medicine , chemistry , biology , biochemistry , staphylococcus aureus , bacteria , genetics
The current study was designed to determine the antioxidant effects of vitamin C and vitamin E against oxidative stress induced by vancomycin in some antioxidants changes in the male rats. The study was conducted in the animal house of the Faculty of Science/University of Kufa for the period from April, 2018 to May, 2018 on 119 animals of male rats aged 2.5–3 months and the weight of 150-200 gm. Two experiments designed in this study addressed the first and two experiments to study the oxidative effect of vancomycin in addition to the protective effects of vitamin C and vitamin E to reduce these effects in the treatment of animals for one week and three weeks with vancomycin and vancomycin plus vitamins. The results indicated a significant increase (p < 0.05) in the MDA, CAT, and significant decrease (p < 0.05) in SOD, and GPX. In the animals treated with vancomycin 40,60 mg/kg only compared to the control group for the two periods of administration at the same time occur a significant decrease(p < 0.05) in the MDA, CAT and a significant increase (p < 0.05) in the SOD and GPX after treated animals with vancomycin 40,60 mg/kg with vitamin C and vitamin E for a period of one and three weeks compared with vancomycin group.
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