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Synthesis and Characterization of Some New Heterocyclic Derivatives and Studying of their Biological Activity (Anti-Bacteria)
Author(s) -
Shaimaa A. Behjet,
Zahraa F. Khudair
Publication year - 2020
Publication title -
international journal of pharmaceutical quality assurance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.114
H-Index - 7
ISSN - 0975-9506
DOI - 10.25258/ijpqa.11.1.6
Subject(s) - chemistry , thioglycolic acid , imidazole , tetrazole , sodium azide , carbon 13 nmr , thiazolidine , organic chemistry , acetophenone , glycine , schiff base , amino acid , combinatorial chemistry , stereochemistry , biochemistry , catalysis
The azo compound is consists of (–N=N–) group in their structure, connected with aromatic ring and Heterocyclic system.1 its formed by conjugation reaction between a diazonium salt and a conjugation agent.2 Azo, have applications such as inhibition of DNA RNA, dyes, nitrogen fixation, antibacterial.3 Schiff bases or azomethine (C=N) Consisting of from condensation an amino compound and carbonyl compound.4 Schiff base derivatives exhibit biological activities such as significant exhibit antidepressant and cardiac stimulant, anticonvulsant antitumor activity, Candida albicans growthinhibitory anti.5,6 All Heterocyclic Tetrazole we synthesis have a high biological activity such as five-membered.7 It has versatile applications in various medicinal chemistry, synthetic chemistry.8 Thiazolidinones (are unsaturated ring five-membered).9 Thiazolidines are heterocyclic compounds that have biological activity and semiconductor properties. The thiazolidine ring consists of nitrogen and sulfur atoms. Thiazolidine compounds are known to exhibit interesting and pharmacological activity. Specifically, they are applied, such as antiseizure, fungicida ic anti bacterial, antitubercular, antifungal, antiamoebic, diabetic and, anticonvulsant, hypoglycemic and non-narcotic analgesic.10, 11 Imidazolidine are compound five-member heterocyclic contain nitrogen, carbon, and oxygen atoms in their ring structure.12 Imidazolidines are a well-known type of organic compound of excess interest due to their numerous pharmaceutical applications such as, hypotension, anticarcinogenic, or antibacterial.13 Quinazolines and quinazolinones are kinds of fused heterocycles that are of appreciable interest because of the diverse arear of their biological properties.14 Activities of quinazoline derivatives, involve, anti-cancer anti-inflammation, analgesia, anti-virus, anti-spam, anti-bacterial, anti-cytotoxin.15 Thiazines are an important kind of heterocycles contain one atom nitrogen, one sulfur, and Oxygen.16

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