Study the Biological Activity for Shiff Base and Β–Lactam Compounds that Synthesis and Identification from Pyrimidine Derivatives

In this research, we prepare as a medium derivative to Prepareβ-Lactam Schiff bases form a significant class of compounds in medicinal and pharmaceutical chemistry with several biological applications that include antibacterial, antifungal, and antitumor activity.1 Schiff bases of aliphatic aldehydes are relatively unstable and are readily polymerizable while those of aromatic aldehydes, having an effective conjugation system are more stable.2 According to the first synthesis of compounds by the scientist, Staudinger in 19073 beta-lactam compounds consist of a four-ring connected with six-membered of dihydrothiazin ring called cephalosporins, but if it is connected with five-membered thiazolidine ring called penicillins,4 β-lactamases are a family of bacterial enzymes that cleave penicillins and cephalosporins with high catalytic efficiency and render these bacteria resistant to β-lactam antibiotics.5,6 Also, the 2-aze tidinone (ß-lactam) is the essential feature of a large number of biologically active compounds, namely penicillin’s, cephalosporin’s, carmona, thienamycine, and the norcardicins.7,8 Enzyme function prediction is a very challenging task in Bioinformatics. It is the most esse ntial mole cule in our life. Enzyme is responsible for catalysis of biochemical reaction for metabolism, structuring the organs and for maintenance of cellular component.9,10 Cancer is an important reason causing death in many countries. So cancer studies become as interest ing research field. Many research groups approached cancer treatment with some different strategies.11,12 Primary liver cancers include hepatocellular carcinomas (HCCs), cholangiocarcinomas (CCAS) combined HCC-CCAs, hepatoblastomas, and fibrolamellar hepatocellular carcinomas (FLHCCS).13