A Study of Retention Behavior and Method Development of Salbutamol Sulfate in Hydrophilic Interaction Chromatography | Zendy

Ashraf Saad Rasheed | Zendy; Ali Saad Ali | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Study of Retention Behavior and Method Development of Salbutamol Sulfate in Hydrophilic Interaction Chromatography

Author(s) -

Ashraf Saad Rasheed,

Ali Saad Ali

Publication year - 2020

Publication title -

international journal of drug delivery technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.133

H-Index - 9

ISSN - 0975-4415

DOI - 10.25258/ijddt.10.3.6

Subject(s) - chromatography , chemistry , salbutamol , sulfate , acetonitrile , hydrophilic interaction chromatography , calibration curve , phase (matter) , high performance liquid chromatography , organic chemistry , detection limit , medicine , asthma

For chromatographical separation and estimation of salbutamol sulfate, zwitterionic stationary phases with large capacity were obtained by zwitter-molecules attached to a polystyrene-divinylbenzene (PS/DVB) particle. Salbutamol sulfate retention activity was studied with eluent at various pH mobile phase, mobile phase concentrations, and acetonitrile (ACN) percentage. The methods of separation are based on separating the salbutamol sulfate into hydrophobic and cations interactions. Linearity of 0.01 to 0.9 μg.mL-1 for two columns was developed with direct calibration curves, %RSD percent (0.48 ± 0.12 and 0.49 ± 0.22), LoD (0.058 and 0.04 μg.mL-1), and LoQ (0.203 and 0.14 μg.mL-1) were created, respectively.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research