Effects of Melatonin on Some Bone Mineralization Biomarkers for Overweight or Obese Perimenopause Women; A Possible Role in Osteoporosis Treatment | Zendy

Hiba Dawood | Zendy; Maysara M. Albadran | Zendy; Noor Mohammed Aulraman | Zendy; Renna D. Abdul-Wahhab | Zendy; Falah Hassan Shari | Zendy

Open Access

Effects of Melatonin on Some Bone Mineralization Biomarkers for Overweight or Obese Perimenopause Women; A Possible Role in Osteoporosis Treatment

Author(s) -

Hiba Dawood,

Maysara M. Albadran,

Noor Mohammed Aulraman,

Renna D. Abdul-Wahhab,

Falah Hassan Shari

Publication year - 2020

Publication title -

international journal of drug delivery technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.133

H-Index - 9

ISSN - 0975-4415

DOI - 10.25258/ijddt.10.2.6

Subject(s) - melatonin , endocrinology , medicine , osteocalcin , bone remodeling , osteoporosis , vitamin d and neurology , chemistry , alkaline phosphatase , biochemistry , enzyme

Background: Melatonin has shown to play an important role in many physiological functions, but its effects on bone metabolism were not well defined in humans. Objective: Evaluation of the effects of oral melatonin used for two months on bone mineralization biomarkers for women in perimenopause. Methods: Interventional double-blind placebo-control study, in which 60 women in perimenopause (age range 46–48) assigned in either control (n = 30) or study (n = 30) group. The last group received 3 mg tablet of melatonin once a day at night for two months. Parameters measured were serum osteocalcin, 25(OH) vitamin D, calcium, and C-terminal telopeptide of type 1 collagen (CTX-1). Result: Melatonin led to significant rise (p < 0.05) in osteocalcin, serum vitamin D, serum calcium, and CTX-1 as compared with control values. Conclusion: Melatonin showed positive effects on bone health by a significant increase in some bone mineralization biomarkers.

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