Therapeutic Drug Monitoring of Cytotoxic Drugs | Zendy

Qutaiba Ahmad Al Khames Aga | Zendy; Yazan A. Bataineh | Zendy; Hala Mousa Sbaih | Zendy

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Therapeutic Drug Monitoring of Cytotoxic Drugs

Author(s) -

Qutaiba Ahmad Al Khames Aga,

Yazan A. Bataineh,

Hala Mousa Sbaih

Publication year - 2020

Publication title -

international journal of drug delivery technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.133

H-Index - 9

ISSN - 0975-4415

DOI - 10.25258/ijddt.10.2.16

Subject(s) - drug , cytotoxic t cell , therapeutic drug monitoring , therapeutic index , pharmacology , pharmacokinetics , medicine , plasma concentration , chemistry , in vitro , biochemistry

The majority of anticancer drugs are recognized with a narrow therapeutic index, the area under the plasma levels vs. time curve (AUC) is the common pharmacokinetic (PK) parameter, which utilizes specifically for cytotoxic drugs. Therapeutic drug monitoring (TDM) approach in these drugs has never been completely applied due to different reasons, for example, the use of combination chemotherapies for different malignant tumors, and the behavior of intracellular compounds; it is possible to eliminate these limitations by using specific concentrations of cytotoxic drugs and measure AUC after certain conditions. In this review article, we discussed the common TDM parameters, methods of analysis, and some of drug interactions for a group of cytotoxic drugs.

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