Linking Lifestyle Factors to Complex Pain States: 3 Reasons Why Understanding Epigenetics May Improve the Delivery of Patient-Centered Care

Persistent pain is determined by a diverse and ever-changing combination of biology, psychology, and society. Research suggests a need to embrace a patient-centered, biopsychosocial approach to improve outcomes. Only through in-depth understanding of complex mechanisms and by using mechanism-based reasoning can the clinician tailor interventions-the basic tenet of patient-centered care. Epigenetics is helping to unravel complex underlying mechanisms and might have at least 3 major clinical implications for orthopaedic and sports physical therapists. First, it promotes mechanism-based clinical reasoning by improved understanding of the pathophysiology of many health conditions and the underlying mechanisms of action of commonly used interventions. Second, it might help patient subgrouping, allowing more targeted interventions. Finally, it might be used as a biomarker to monitor the effects of environmental factors and lifestyle interventions on health. For these reasons, the authors urge clinicians and clinical researchers to follow this rapidly growing area of research, as it might be soon contributing to patient assessment. J Orthop Sports Phys Ther 2019;49(10):683-687. doi:10.2519/jospt.2019.0612 .