Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Ekstrak Biji Ramania (Bouea macrophylla Griff) dengan Asam Oleat (Oleic Acid) sebagai Minyak Pembawa

B.macrophylla seed extract has strong antioxidant activity but has low solubility and bioavailability. To overcome low solubility and bioavailability of B.macrophylla seed extract it was formulated into self nanoemulsifying drug delivery system (SNEDDS) using oleic acid as a carrier oil. The results showed that the most optimal composition of SNEDDS B.macrophylla seed extract consisted of a combination of tween 20 : propylenglycol : oleic acid (0.5 : 3 : 1.5 and 0.5 : 3.38 : 1,12) in 5 mL which has an emulsification time with an average time of 19.03 seconds and 15.2 seconds; transmittance value of 92.8% and 94.2%; droplet size of 176,8 nm and 161,1 nm; polidisperse index of 0,357 and 0,364; also the IC50 value of B.macrophylla seed extract 1.757 μg / mL.