Obstructive Sleep Apnea Syndrome: Links Betwen Pathophysiology and Cardiovascular Complications | Zendy

Eugenia Hopps | Zendy; Gregorio Caimi | Zendy

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Obstructive Sleep Apnea Syndrome: Links Betwen Pathophysiology and Cardiovascular Complications

Author(s) -

Eugenia Hopps,

Gregorio Caimi

Publication year - 2015

Publication title -

clinical and investigative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 47

eISSN - 1488-2353

pISSN - 0147-958X

DOI - 10.25011/cim.v38i6.26199

Subject(s) - medicine , obstructive sleep apnea , endothelial dysfunction , cardiology , pathophysiology , oxidative stress , coronary artery disease , stroke (engine) , population , inflammation , mechanical engineering , environmental health , engineering

The prevalence of obstructive sleep apnea syndrome (OSAS) is increasing, especially in the middle-aged population. OSAS is associated with an elevated risk of cardiovascular morbidity and mortality. Arterial hypertension is often the first consequence of OSAS, but the most severe complications are coronary artery disease, stroke and arrhythmias. The aim of this review was to analyze the several mechanisms involved in the development of the cardiovascular events, such as endothelial dysfunction accompanied by a pro-inflammatory and pro-oxidant status, hemorheological alterations, hypercoagulability and imbalance between matrix metalloproteases and their inhibitors.

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