Up-regulation of ITCH is associated with down-regulation of LATS1 during tumorigenesis and progression of cervical squamous cell carcinoma | Zendy

Ying Zhou | Zendy; Tao Feng | Zendy; Yong Cheng | Zendy; Fei Xu | Zendy; Yao Fengqiu | Zendy; Dingqing Feng | Zendy; Lin Miao | Zendy; Weihua Xiao | Zendy; Bin Ling | Zendy

Open Access

Up-regulation of ITCH is associated with down-regulation of LATS1 during tumorigenesis and progression of cervical squamous cell carcinoma

Author(s) -

Ying Zhou,

Tao Feng,

Yong Cheng,

Fei Xu,

Yao Fengqiu,

Dingqing Feng,

Lin Miao,

Weihua Xiao,

Bin Ling

Publication year - 2014

Publication title -

clinical and investigative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 47

eISSN - 1488-2353

pISSN - 0147-958X

DOI - 10.25011/cim.v37i6.22243

Subject(s) - carcinogenesis , cervical intraepithelial neoplasia , immunohistochemistry , epithelium , pathology , malignant transformation , cervical cancer , koilocyte , cervix , cancer research , stage (stratigraphy) , medicine , biology , cancer , paleontology

The molecular basis for the normal cervical squamous epithelium advance to cervical intraepithelial neoplasia (CIN I, CIN II, CIN III) and ultimately to invasive carcinoma has not yet been defined. We explored the abnormal expression of ITCH (AIP4) and its degrading substrate Large Tumor Suppressor 1 (LATS1) in CINs and cervical cancers, which might disrupt the normal differentiation of the cervical epithelia and contribute to the tumorigenesis of the cervix.

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