MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis | Zendy

Jin He | Zendy; Yue Yan | Zendy; Chunsheng Dong | Zendy; Sidong Xiong | Zendy

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MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis

Author(s) -

Jin He,

Yue Yan,

Chunsheng Dong,

Sidong Xiong

Publication year - 2013

Publication title -

clinical and investigative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 47

eISSN - 1488-2353

pISSN - 0147-958X

DOI - 10.25011/cim.v36i2.19573

Subject(s) - myocarditis , viral myocarditis , apoptosis , microrna , medicine , pathogenesis , immunology , cancer research , biology , gene , biochemistry

The participation of microRNAs (miRNAs) in cardiovascular diseases suggests them as potential targets for novel preventive and therapeutic strategies. In this study, the key myocardial miRNA, miR-21, was identified in the murine coxsackievirus B3 (CVB3)-induced myocarditis model and its contribution to disease progression was explored.

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