Open AccessKi-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia
Author(s) -
Weide Zhong,
Jinyu Peng,
HE Hui-chan,
Dinglan Wu,
Zhaodong Han,
Xuecheng Bi,
Qi-Shan Dai
Publication year - 2008
Publication title -
clinical and investigative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 47
eISSN - 1488-2353
pISSN - 0147-958X
DOI - 10.25011/cim.v31i1.3136
Subject(s) - proliferating cell nuclear antigen , lncap , hyperplasia , prostate cancer , prostate , grading (engineering) , immunohistochemistry , cell cycle , cell growth , proliferation marker , pathology , medicine , cancer , biology , ecology , genetics
Ki-67 is a proliferation-associated nuclear antigen and is expressed in all cycling cells except for resting cells in the G0-phase. PCNA is an acidic nuclear protein and has been recognized as a histologic marker for the G1/S phase in the cell cycle. Ki-67and PCNA labeling indices are considered to reflect cell proliferation, particularly, growth fraction. The purpose of this study is to investigate the expression levels of Ki-67 and PCNA in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their potential on the early diagnosis of PCa.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom