A New Protocol for Collagen-Induced Local Arthritis Model in Balb/c Mice | Zendy

Gökçen Güvenç | Zendy; Mehmet Karaçay | Zendy; Ahmet Akkoç | Zendy; Kübra Çiftçi | Zendy; Haluk Barbaros Oral | Zendy; Murat Yalçın | Zendy

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A New Protocol for Collagen-Induced Local Arthritis Model in Balb/c Mice

Author(s) -

Gökçen Güvenç,

Mehmet Karaçay,

Ahmet Akkoç,

Kübra Çiftçi,

Haluk Barbaros Oral,

Murat Yalçın

Publication year - 2018

Publication title -

turkish journal of immunology

Language(s) - English

Resource type - Journals

ISSN - 2147-8325

DOI - 10.25002/tji.2018.771

Subject(s) - collagen induced arthritis , balb/c , arthritis , chemistry , immunology , medicine , immune system

Numerous models have been described to study the pathogenesis of rheumatoid arthritis, and to develop new therapies; but each of these models has their own limitations. Nowadays, the collagen-induced arthritis (CIA) mouse model is the most commonly used model for rheumatoid arthritis studies in certain mouse strain like DBA/1 mouse. This study aimed to describe a new protocol for local induction of arthritis in Balb/c mice, including the monitoring of clinical arthritis and the protocols for histological examination of paws of mice.

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