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Aim: Metastasis to the cervical lymph nodes in laryngeal carcinomas is a factor reducing survival significantly. The present study aimed to reveal the association of lymph node metastasis with lymphatic vessel density and microvessel density in the intratumoral and extra-tumoral areas of laryngeal squamous cell carcinoma. Methods: Eighty-six cases diagnosed with laryngeal squamous cell carcinoma in Pathology Department of Erciyes University Faculty of Medicine between 2000-2006 were included in the present study. Lymphatic vessel density and microvessel density were assessed with D2-40 which is an immunohistochemical marker in intratumoral and extra-tumoral areas and CD34, respectively. The results were compared with tumor grade, tumor localization, and lymph node metastasis. Results: Intratumoral and extra tumoral lymphatic vessel density value were 8.93±12.5 and 24.1±20.1, respectively (p=0.001). Mean intra tumoral microvessel density was calculated as 217.53±89.8 while extra tumoral microvessel density was calculated as 330.43±92.4 (p=0.001). Intratumoral lymphatic vessel density value was higher in the well-differentiated tumors compared to the poorly differentiated tumors but no significant result was obtained (p=0.100). Extra tumoral microvessel density value was found to be significantly higher in the poorly differentiated tumors (p=0.05). Intratumoral microvessel density value was significantly lower in tumors with lymph node metastasis (p=0.028). Extra-tumoral lymphatic vessel density value was higher in both groups with and without lymph node metastasis, however, no statistically significant result could be

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