Autoimmune-Related Nasal Septum Perforation: A Case Report and Systematic Review | Zendy

Lohitha Guntupalli | Zendy; Kunjan Patel | Zendy; Farhoud Faraji | Zendy; Joseph D. Brunworth | Zendy

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Autoimmune-Related Nasal Septum Perforation: A Case Report and Systematic Review

Author(s) -

Lohitha Guntupalli,

Kunjan Patel,

Farhoud Faraji,

Joseph D. Brunworth

Publication year - 2017

Publication title -

allergy and rhinology

Language(s) - English

Resource type - Journals

eISSN - 2152-6575

pISSN - 2152-6567

DOI - 10.2500/ar.2017.8.0191

Subject(s) - nasal septum , perforation , medicine , anatomy , nose , engineering , mechanical engineering , punching

Inflammatory injury of nasal respiratory mucosa is a common feature of multisystem autoimmune disease. Certain autoimmune disorders are associated with nasal septum perforation (NSP). We performed a systematic review of the literature to better understand the association of NSP with specific autoimmune disorders. This is a case report of a 29-year-old woman with a history of arthralgia, autoreactive antibody titers, platelet dysfunction, and NSP. The constellation of symptoms and potential familial involvement indicated that the NSP in this patient was an early sign of an autoimmune disorder, an unknown autoimmune disorder, or a known disease with incomplete penetrance.

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