Chemical Studies on Tobacco Smoke: I. The Quantitative Determination of Indoles in Cigarette Smoke | Zendy

D. Hoffmann | Zendy; Joseph E. Rubin | Zendy

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Chemical Studies on Tobacco Smoke: I. The Quantitative Determination of Indoles in Cigarette Smoke

Author(s) -

D. Hoffmann,

Joseph E. Rubin

Publication year - 1966

Publication title -

beiträge zur tabakforschung international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.253

H-Index - 16

eISSN - 1612-9237

pISSN - 0173-783X

DOI - 10.2478/cttr-2013-0134

Subject(s) - indole test , chemistry , chromatography , cigarette smoke , skatole , methanol , smoke , hexane , tobacco smoke , gas chromatography , organic chemistry , toxicology , biology

A method for the quantitative determination of indole and alkylated indoles in cigarette smoke is described. The analysis consists of distributions between n-hexane / methanol-water (4:1); n-hexane / methanol-water (1:2); column chromatography on Florosil and gas chromatographic separation on 20 % Apiezon L at 155°C. Quantitative data are secured by use of C14-labelled indole as internal standard. In the smoke of an 85 mm blended United States cigarette without filter tip were determined 13.9 µg indole, 14.0 µg skatole, 4.2 µg 3-ethylindole, and 0.21 µg 3-n-propylindole. The presence of an admixture of dimethylindoles was tentatively established; their concentration was below 0.03 µg per cigarette

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