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Artificial intelligence, defined as a system capable of interpreting and learning from data to produce a specific goal,1 has made significant advances in the field of neglected tropical diseases. Specifically, artificial intelligence is increasingly applied to the task of interpreting images of such diseases and generating accurate and reliable diagnoses that may ultimately inform management of these conditions. Neglected tropical diseases affect over a billion people globally and are a significant source of morbidity and mortality in lowand middle-income countries.2 Artificial intelligence has the potential to transform how such diseases are diagnosed and may contribute to enabling clinical and public health delivery in lowand middle-income countries. For example, artificial intelligence applied to neglected tropical disease diagnosis may help drive pointof-care clinical decision-making, identify outbreaks before they spread and help map these diseases to guide public health surveillance and control efforts. The latest research in this field demonstrates that novel diagnostic tools, such as mobile phone microscopes have rapidly improved diagnostic characteristics and broadened the scope of pathogens tested, and have excellent functionality in neglected tropical disease-endemic settings.3,4 Such devices are already being field tested and implemented on a limited scale, for example in Côte d’Ivoire.5 However, careful consideration to several ethical concerns arising from artificial intelligence-driven diagnoses of neglected tropical diseases in low-resource settings is critical for maximizing the benefit of this technology.6 Artificial intelligence applications focused on image-based diagnoses is still in its infancy and therefore, now is an opportune time to ensure that these applications develop within an ethical framework. Here, we outline important ethical challenges faced by lowand middle-income countries that may benefit from the implementation of these technologies. Key issues discussed include the interrelationships between stakeholder engagement, consent, data security, accessibility of technology, adhering to current and evolving care standards and deciding how to effectively use resources. Addressing these issues during the design phase of artificial intelligence technology will facilitate its timely implementation and maximize public health benefit. Most published studies focusing on the development of artificial intelligence tools for image-based diagnoses are conducted in laboratories based in high-income countries. Consequently, the limited engagement of scientists and clinicians from endemic regions may restrict the utility, and eventually scale, of these technologies in precisely the countries that would benefit the most. Therefore, several stakeholders should be involved from the earliest phases in the development of artificial intelligence tools.7 These stakeholders include data scientists and engineers from both lowand middle-income countries affected by neglected tropical diseases and those from high-income countries currently working in artificial intelligence diagnostics. Pairing teams of data scientists and engineers would enable capacity building in lowand middle-income countries where there is currently limited infrastructure to develop such diagnostic tools. Other important stakeholders include clinical, public health, governmental and citizen representation from lowand middleincome countries affected by these diseases. Such groups are critical in the identification of priority areas, shaping research questions and implementing the technology into routine health-care use. Private industry and governmental bodies should also be instrumental in the scale-up, licensing and regulation of new diagnostic tools, and their involvement and support during concept development may help streamline product development.8 Addressing ethical issues surrounding informed consent, an issue closely intertwined with data security, is vital in the development of artificial intelligence image-based diagnostic tools for neglected tropical diseases. Diagnostic tests inherently involve some form of biologic sample collection from a patient and this procedure is frequently connected to patient-identifying information. Although these diagnoses may be performed at the point of care,9 the collected specimens and images may be subsequently used to train and improve machine-learning algorithms. Individuals providing samples must consent to their biologic sample, and perhaps other personal data. Similarly, individuals must be notified of which personal information is being used and stored, where it is being stored, who has access to this data, how it is being accessed and how this personal information is being used or may be used in the future.1,6 Given that much of this diagnosis technology has been developed in high-income countries for use in lowand middle-income countries, special attention is required. Therefore, the informed consent process Artificial intelligence, diagnostic imaging and neglected tropical diseases: ethical implications Alon Vaisman, Nina Linder, Johan Lundin, Ani Orchanian-Cheff, Jean T Coulibaly, Richard KD Ephraim & Isaac I Bogoch