Removal kinetics of exchange transfusion.

Exchange transfusion has just a few elective indications: the therapy of haemolytic disease of the newborn (HDN) and cases in which red cell exchange is appropriate but the child is too small to use a cell separator. Exchange transfusion has several positive effects in the therapy of HDN: it removes the neonatal red cells, which are destined to be destroyed and hence to generate bilirubin, the already produced bilirubin, and the offending antibody1. Moreover, exchange transfusion also corrects anaemia, if present1.