A Clinical Evaluation of Management of Amavata with Rasonadi kwatha, w.s.r. to Rheumatoid Arthritis

Purpose: To evaluate the role of Rasonadi kwatha, a classical medicament in the management of Amavata, w.s.r. to Rheumatoid Arthrits, which is attributed with best Amavatahara property, considering a trend of progressively increasing incidence of the condition. Methods: The trial drug Rasonadi kwatha was prepared as per the classical method of Kashaya kalpana. Total of 47 patients of Amavata fulfilling the inclusion criteria were registered, of which 30 completed the course of intervention, in a single armed, prospective, open label, cohort study, with pre and postintervention analysis design. Descriptive data including Mean, Standard Deviation (SD), Standard Error (SE), t-value and percentages were calculated for all variables in the trial group. The post treatment changes were assessed by paired Student t-test, taking 0.05 as the level of significance. Results: Effect of the intervention on Subjective criteria including Signs and symptoms of Amavata and objective criteria including Disease Activity Score 28, Grip strength, Foot Pressure and Range of Movement was statistically significant with P value 0.001 after completion of treatment. The trial drug showed 36.67% of Moderate improvement and 53.33% of mild improvement in subjects of Amavata in the present study. Conclusion: The formulation Rasonadi kwatha is efficacious in management of the disease Amavata w.s.r. to Rheumatoid Arthritis. The formulation is Ruksha (Dry) and Ushna (Hot potency) and thus it is a potent Amapachaka (digesting the Ama), breaking the primary pathogenesis of the disease. It showed statistically significant improvements in Samanya lakshanas and good results in Pradhana lakshanas of Amavata.