Efficient Microwave-Assisted Solvent-Free Synthesis and Molecular Docking Studies of 2-pyridone derivatives as Anticancer Agents and Evaluation of Cytotoxic Effects | Zendy

Magda H. Abdellattif | Zendy

Open Access

Efficient Microwave-Assisted Solvent-Free Synthesis and Molecular Docking Studies of 2-pyridone derivatives as Anticancer Agents and Evaluation of Cytotoxic Effects

Author(s) -

Magda H. Abdellattif

Publication year - 2016

Publication title -

journal of advances in chemistry

Language(s) - English

Resource type - Journals

ISSN - 2321-807X

DOI - 10.24297/jac.v12i4.2175

Subject(s) - combinatorial chemistry , chemistry , cancer cell lines , docking (animal) , stereochemistry , cancer , cancer cell , biology , medicine , genetics , nursing

A green protocol will be used to synthesize a novel series of 3-cyano-5- arylazo-pyridones (9a-c) and (10d-i). Methodology: Structures of the new products will be confirmed on the basis of spectroscopic data (FT-IR, 1D, NMR) as well as alternative synthetic routes, anticancer cell-line will be investigated and also molecular docking studies will be applied. Results: The activity against different cancer cell-line will be studied. Compounds with electron withdrawal group showed the highest activities.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research