Open AccessSYNTHESIS AND CHARACTERIZATION OFGOLDNANOPARTICLESUSING CEFOTAXIMSODIUM AND ITS SCHIFF BASE DERIVATIVE WITH 4-N,N-DIMETHYLAMINO BENSALDEHYDEAS REDUCING ANDSTABILIZING AGENTS
Author(s) -
Prof. Dr. Ahlam J. Abdulghani,
Rasha Kudher Hussain
Publication year - 2015
Publication title -
journal of advances in chemistry
Language(s) - English
Resource type - Journals
ISSN - 2321-807X
DOI - 10.24297/jac.v11i8.2190
Subject(s) - schiff base , benzaldehyde , chemistry , nuclear chemistry , spectrophotometry , derivative (finance) , fourier transform infrared spectroscopy , reducing agent , conjugated system , carboxylate , base (topology) , ligand (biochemistry) , polymer chemistry , medicinal chemistry , catalysis , organic chemistry , chromatography , polymer , chemical engineering , mathematics , mathematical analysis , financial economics , engineering , receptor , biochemistry , economics
Conjugated GNPs were synthesized by one step reaction of AuCl4- with cefotaxim (CFX) and its Schiff base derivative with 4-N,N-dimethylamino benzaldehyde [sodium 3-(acetoxymethyl)-7-((2Z)-2-(2-(4-dimethylamino) benzylideneamino) thiazol-4-yl)-2-(methoxyimino) acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate] (SCFX)without the need of reducing and functionalizing agents. The reduction process was monitored by uv-visible spectrophotometry and the synthesized GNPs were characterized by TEM, SEM, AFM and XRD analysis. The conjugation of GNPs with the two ligands was characterized by FTIR spectrophotometry. The size, morphology, and stability of GNPs were varied with concentration ratio of ligand/Au(III), pH medium and reaction temperature
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