Obesity and inflammatory skin diseases | Zendy

Satoshi Nakamizo | Zendy; Tetsuya Honda | Zendy; Kenji Kabashima | Zendy

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Obesity and inflammatory skin diseases

Author(s) -

Satoshi Nakamizo,

Tetsuya Honda,

Kenji Kabashima

Publication year - 2017

Publication title -

trends in immunotherapy

Language(s) - English

Resource type - Journals

ISSN - 2573-5985

DOI - 10.24294/ti.v1.i2.98

Subject(s) - psoriasis , atopic dermatitis , medicine , obesity , inflammation , immunology , diabetes mellitus , adipose tissue , disease , bioinformatics , biology , endocrinology

Obesity has become a significant public health problem since it may cause many chronic diseases, including type 2 diabetes, cardiovascular diseases, liver diseases, and some cancers. Recent studies have shown that obesity is a major risk factor for the development of inflammatory skin diseases, including eczema, atopic dermatitis, and psoriasis. Inflammatory cytokines produced from adipose tissue and activation of innate immunity are considered as important factors in obesity-induced inflammation. However, the molecular mechanisms by which obesity affects the development of inflammatory skin diseases are not well understood. In this review, we will discuss the relationship between the underlying mechanisms linking obesity and inflammatory skin diseases based on the latest researches.

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