A simple and Sensitive Spectrophotometric Method for the Determination of Trace Amounts of Sulfadiazine in Pharmaceutical Drugs Sample | Zendy

Israa Talib | Zendy

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A simple and Sensitive Spectrophotometric Method for the Determination of Trace Amounts of Sulfadiazine in Pharmaceutical Drugs Sample

Author(s) -

Israa Talib

Publication year - 2018

Publication title -

diyala journal for pure science

Language(s) - English

Resource type - Journals

eISSN - 2518-9255

pISSN - 2222-8373

DOI - 10.24237/djps.1402.368a

Subject(s) - sulfadiazine , trace (psycholinguistics) , chromatography , simple (philosophy) , sample (material) , chemistry , philosophy , biochemistry , antibiotics , linguistics , epistemology

This study includes a simple and sensitive spectrophotometric method for the estimation of trace amounts of sulfadiazine in aqueous solution utilizing oxidative coupling reaction of sulfadiazine with pyrocatechol in the existence of potassium periodate (KIO4) in acidic medium to yield a water-soluble dye which appear a maximum absorbance at 515 nm. The linearity is in the concentration range 0.2 20 μg/ml of SDZ, the molar absorptivity 1.2765× 10 liter. mol .cm and the relative error ranges from 1.20 1.36 % depending on the concentration level of SDZ. The study was successfully applied to estimate the sulfadiazine in pharmaceutical drugs sample in the form of injections and burn cream.

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